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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(8): 1107-1116
Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model
Sujin Lee1 • Ji Sun Lim2 • Hyun Seok Yun1 • Yoonsu Kim1 • Soojung Jeong1 • Seong Deok Hwang3 • Jong Won Kim4 • Jisun Oh2 • Jong-Sang Kim1,2
1School of Food Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea 2 Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea 3 Fugencelltech Co., Ltd., Gyeongsangbuk-do 37272, Republic of Korea 4 Fugenbio Co., Ltd., Seoul 06746, Republic of Korea
ABSTRACT
Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was dissolved and orally administered to scopolamine-treated C57BL/6J mice followed by behavioral tests using the Y-maze, passive avoidance, and Morris water maze tasks. CL administration at a daily dose of 200 mg/kg body weight resulted in restoration of exploration reduction and improvement of associative and spatial learning and memory impairment in scopolamine-treated mice. Concomitantly, heme oxygenase-1 was highly expressed in the hippocampal region of CL-administered mice. Moreover, the ethanolic extract of CL significantly increased the transcriptional activity of antioxidant response element and attenuated the glutamate-induced cytotoxicity in HT22 mouse hippocampal neuronal cells. These findings suggest that the CL intake can confer a beneficial effect on learning and memory presumably through protecting hippocampal neuronal cells from oxidative stress-induced damage.
KEYWORD
Ceriporia lacerata · Neuroprotection · Learning and memory · Hippocampal neuron · Heme oxygenase-1
Food Science and Biotechnology 2021 ; 30(8): 1107-1116
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