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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(5): 755-764
Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats
Yumei Jiang1,4 • Na Zhang1 • Yawen Zhou2 • Zhongkai Zhou1,3 • Yu Bai1 • Padraig Strappe3 • Chris Blanchard3
1 Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China 2 College of Food Science and Technology, Nanjing Agriculture University, Nanjing 210095, China 3 ARC Functional Grains Centre, Charles Sturt University, Wagga Wagga, NSW 2678, Australia 4 College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China
ABSTRACT
Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separately on type 2 diabetic mellitus (T2DM) rats. This work was to explore the effects of administering encapsulated GLS within RS (referred to as EGLS) in the T2DM rats, which were induced by streptozotocin (STZ). The EGLS was orally administered to rats for 28 days. The parameters of glycometabolism and lipometabolism were evaluated, and fecal microbiota composition was investigated. The results showed that EGLS significantly enhanced glycometabolism and lipometabolism parameters in T2DM rats, which might be associate with the enhancement of the glucose and lipid metabolism, insulin secretion, and glycogen synthesis and reduced lipogenesis. Furthermore, the intervention of EGLS also reduced the Proteobacteria community and improved dysfunctional gut microbiota. This study indicated EGLS may be a potential candidate for dietary intervention to modulate diabetes.
KEYWORD
Ganoderma lucidum spores · Resistant starch · Encapsulation · Diabetes · Gut microbiota
Food Science and Biotechnology 2021 ; 30(5): 755-764
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