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한국식품과학회지
→ 한국식품과학회지2021 ; 53(2): 165-173
Inhibitory effect of ethanol extract of Codonopsis lanceolata against oxidative stress and disruption of tight cell junction in NCI-H441 cells after exposure to urban particulate matter
더덕 에탄올 추출물의 도시미세먼지 노출로 인한 폐 세포 산화스트레스 발생과 세포밀착연접 손상 억제 효과
Hee-Jung So1,†, Su-Hyun Chun2,†, Jin-Won Lee3, and Kwang-Won Lee4,*
1Department of Food Bioscience and Technology, Graduate School of Life and Environmental Science, Korea University 2Institute of Biomedical Science and Food Safety, Korea University 3Faculty of Health and Food/Medicinal Plant, Suwon Women University 4Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
소희정1,† · 전수현2,† · 이진원3 · 이광원4,*
1고려대학교 생명환경과학대학원 식품공학과, 2고려대학교 식품생의학안전연구소 3수원여자대학교 보건식품학부 약용식물과, 4고려대학교 일반대학원 생명공학과
ABSTRACT
One of the major sources of air pollution is urban particulate matter (UPM), which causes lung diseases involving oxidative stress, inflammation, and cancer. Codonopsis lanceolata (CL) has been used in East Asia as a traditional oriental medicinal ingredient for lung diseases (e.g., asthma and bronchitis). However, the connection between the impact of CL and UPM in the lungs has rarely been investigated. This study aimed to confirm the inhibitory activity of the ethanol extract of CL (ECL) against oxidative stress and disruption of tight cell junctions in human pulmonary epithelial cells after exposure to UPM. As the lung cells were pre-treated with ECL, the UPM-induced increase in cellular reactive oxygen species production suppressed tight junction proteins (e.g., N-cadherin, fibronectin, occludin, zonula occludens-1, and claudin-4). These results suggest that ECL prevents the possible effects of UPM toxicity on the lungs.
KEYWORD
Urban particulate matter, oxidative stress, Codonopsis lanceolata, antioxidant, tight junction
한국식품과학회지 2021 Apr; 53(2): 165 - 173
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