→ 한국식품과학회지2021 ; 53(2): 154-159
Anti-inflammatory and antioxidant effects of Barringtonia augusta Kurz extract
Barringtonia augusta Kurz 추출물의 항염증 및 항산화 효능 평가
Soo Ho Ryu1, Min Jeong Kim1, Tran The Bach2, and Sung Keun Jung1,*
1School of Food Science and Biotechnology, Kyungpook National University 2Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology (VAST)
류수호1 · 김민정1 · Tran The Bach2 · 정성근1,*
1경북대학교 식품공학부 식품응용공학전공, 2베트남 과학기술원, 생태생물자원 연구소
Barringtonia augusta Kurz is a species of the genus Barringtonia. Although several studies have analyzed the biological activity of B. racemosa Roxb and B. acutangula, the anti-inflammatory and antioxidant effects of B. augusta extract (BKE) remain unclear. Therefore, in this study, we investigated the anti-inflammatory and antioxidant effects of BKE using lipopolysaccharide (LPS) and RAW 264.7. BKE suppressed LPS-induced nitric oxide (NO) and inducible NO synthase expression without affecting RAW 264.7 cell viability. Additionally, BKE showed 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging capacities and inhibited LPS-induced reactive oxygen species production in RAW 264.7 cells. BKE also suppressed LPS-induced phosphorylation of IκB kinase and nuclear factor kappa-B (NF-κB) and p65 translocation from the cytosol to the nucleus in RAW 264.7 cells. These results suggest that BKE is a possible novel material that exerts beneficial antioxidant and anti-inflammatory effects through the inhibition of NF-κB signaling pathways.
Barringtonia augusta Kurz extract, nitric oxide, nuclear factor kappa-B, anti-inflammatory effect, antioxidant effec
한국식품과학회지 2021 Apr; 53(2): 154 - 159