→ 한국식품과학회지2021 ; 53(2): 149-153
Anti-obesity effects of an enzymatic extract of mandarin (Citrus unshiu) peel in 3T3-L1 adipocytes
감귤피 효소적 추출물의 지방세포에서의 항비만 효과
Yebin Jang1, Heejoo Kang2, Jusang Kim2, and Seung-Hong Lee1,3,*
1Department of Medical Science, Soonchunhyang University 2ILHAE Co., Ltd. 3Department of Pharmaceutical Engineering, Soonchunhyang University
장예빈1 · 강희주2 · 김주상2 · 이승홍1,3,*
1순천향대학교 의료과학과, 2(주)일해, 3순천향대학교 의약공학과
Mandarin peel (MP) is a by-product of the processing of citrus juice or other products. This study aimed to investigate the potential anti-obesity effect of an enzymatic extract of MP on the inhibition of adipogenesis in 3T3-L1 adipocytes. The enzymatic extract (MPCE) was prepared using the commercial food-grade carbohydrase Celluclast. Lipid accumulation and triglyceride levels were significantly lower in MPCE-treated cells than in untreated cells. In addition, MPCE treatment reduced the protein expression levels of peroxisome proliferator-activated receptor-γ, CCAAT/enhancerbinding protein α, sterol regulatory element-binding protein 1, and fatty acid-binding protein 4. These results suggest that MPCE inhibits adipogenesis by downregulating the expression levels of adipogenesis-related proteins. Therefore, the current findings demonstrate that MPCE possesses potent anti-obesity properties and could be a potential ingredient in functional food industries.
anti-obesity, enzymatic extract, mandarin, adipogenesis, adipogenesis-related proteins
한국식품과학회지 2021 Apr; 53(2): 149 - 153