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한국식품과학회지
→ 한국식품과학회지2021 ; 53(2): 115-120
Anti-inflammatory activity of Scutellaria Baicalensis root extract in lipopolysaccharide-induced RAW 264.7 cells
LPS로 유도된 RAW264.7세포주에서 황금뿌리 물추출물의 항염증활성
Ye Eun Lee1, Hong Jin Park1, Chung-berm Park1, and Seung-mi Hwang1,2,*
1Department of Efficacy Study, Institute of Jinan red ginseng 2Department of Food Science and Technology, Chonbuk National University
이예은1 · 박홍진1 · 박충범1 · 황승미1,2,*
1진안홍삼연구소, 2전북대학교 식품공학과
ABSTRACT
Scutellaria baicalensis has been used as a traditional medicine for diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation, and respiratory infections. This study examined the anti-inflammatory effect of Scutellaria baicalensis water extract (SWE) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. To evaluate the anti-inflammatory effect of SWE, RAW 264.7 macrophages were stimulated with LPS to induce the production of inflammation-related factors, which were measured by western blotting. In RAW 264.7 cells, SWE inhibited the production of nitric oxide (NO) without causing cell toxicity. SWE also reduced the expression of inducible NO synthase and cyclooxygenase-2 protein, as well as the production of pro-inflammatory cytokines (such as tumor necrosis factor-α). The phosphorylation levels of the mitogen-activated protein kinase family members, such as JNK and p38, were also reduced by SWE. Thus, SWE could be used as a potential anti-inflammatory agent.
KEYWORD
anti-inflammatory, Scutellaria baicalensis, RAW 264.7
한국식품과학회지 2021 Apr; 53(2): 115 - 120
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