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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(2): 305-314
Analysis of chemical compounds and toxicological evaluation of Forsythia suspensa leaves tea
Da-Hong Wang1,2,3 • Meng-Yang Wang1 • Wen-Hao Shen1 • Jiang-Feng Yuan1,2,3
1 College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China 2 Department of Pharmacology, Jinling Hospital, Nanjing 210002, China 3 Henan Engineering Research Center of Food Microbiology, Luoyang 471023, China
ABSTRACT
To determine the compositions of Forsythia suspensa leaves tea (FSLT) and its safety, the chemical compounds were analysed with some methods, and the toxicity was evaluated in Kunming mice and Wistar rats. The results showed that FSLT contained rich flavonoid, lignans, triperpene acids, amino acids, and mineral elements. In the acute toxicity study, none of the mice died, and no obvious poisoning symptoms were observed after 14 days in mice at the dose of 15 mg/gbody weight (bw) FSLT; in the sub-chronic toxicity, no abnormal or dead rat was found at the dose of 1, 3, and 10 mg/gbw during 90 days feeding administration; there was no significant difference in bw and food consumption; no significant differences were found in each hematology and serum biochemistry parameter and organ/body weight ratio comparing with the control experimental group. The results revealed that the FSLT has low or no toxicity via oral administration. Therefore, FSLT is very suitable and safe to be used as a new resource food.
KEYWORD
Forsythia suspensa leaves tea (FSLT) · Chemical compound · Acute toxicity · Sub-chronic toxicity
Food Science and Biotechnology 2021 ; 30(2): 305-314
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