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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(2): 299-304
Mineral-rich Jeju lava sea water suppresses lipid accumulation in 3T3-L1 adipocytes and ameliorates high-fat diet-induced obesity in C57BL/6 J mice
Ye Ji Hyun1 • Ju Gyeong Kim2 • Min Jeong Kim2 • Sung Keun Jung2 • Ji Yeon Kim1
1 Department of Food Science and Technology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea 2 School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea
ABSTRACT
This research aimed to evaluate the potential inhibitory effect of mineral-rich Jeju lava sea water (JLSW) on lipid accumulation. This study optimized the calcium (Ca): magnesium (Mg) ratio (5:1, 2.5:1, 1:1) of JLSW and evaluated the effect on lipid accumulation in 3T3-L1 cells using Oil Red O staining. JLSW with a high Ca:Mg ratio (5:1) suppressed lipid accumulation in 3T3-L1 adipocytes. Based on these in-vitro results, the effects of JLSW on lipid accumulation were investigated in C57BL/ 6 J mice fed high-fat diets for 14 weeks. Epididymal adipose tissue weight was significantly decreased in mice that received JLSW with a hardness of 800 or 100 mg/L compared to HFD. Adipocyte size was significantly reduced in mice treated with JLSW with a hardness of 20 mg/L in comparison with HFD. Thus, long-term intake of JLSW may be expected to have anti-obesity effects due to the reduction of lipid accumulation.
KEYWORD
Jeju lava sea water · Adipogenesis · 3T3-L1 · High-fat diet · Adipocyte size
Food Science and Biotechnology 2021 ; 30(2): 299-304
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