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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(2): 287-297
Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes
Kwan Joong Kim1 • Young Sung Jung2 • Dong Min You3 • Seung Hyun Lee3 • Guemsan Lee4 • Kang- Beom Kwon5 • Dae-Ok Kim1,6
1 Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea 2 Korea Food Research Institute, Wanju 55365, Republic of Korea 3 Food R&D Center, SK Bioland Co., Ltd., Ansan 15407, Republic of Korea 4 Department of Herbology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea 5 Department of Korean Physiology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea 6 Skin Biotechnology Center, Kyung Hee University, Suwon 16229, Republic of Korea
ABSTRACT
Rhodiola rosea L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticate R. rosea L. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer and trnH-psbA of R. rosea L. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds in R. rosea L. rhizome. Rhodiola rosea L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity. Rhodiola rosea L. rhizome and its identified compounds protected neuronal PC- 12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest that R. rosea L. rhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection.
KEYWORD
Acetylcholinesterase · DNA barcoding · Oxidative stress · Salidroside · Tyrosol
Food Science and Biotechnology 2021 ; 30(2): 287-297
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