Food Science and Biotechnology
→ Food Science and Biotechnology 2018 ; 27(1): 227-232
Effects of ginsenosides on regulatory T cell differentiation
Jisu Kim1, Hyeyoung Byeon1, Kyungtaek Im1, Hyeyoung Min1
1College of Pharmacy, Chung-Ang University, 84 Heukseokro, Dongjakgu, Seoul 06974, Korea
Regulatory T cells (Treg cells) are a subpopulation of T cells defined as CD4+Foxp3+CD25+. They mainly function as immunosuppressive T cells by down-regulating the induction and proliferation of effector T cells, but also modulate the immune system by maintaining self-tolerance and preventing autoimmune disease. In this study, the regulatory roles of ginsenosides, one of the active components in ginseng, Panax ginseng C. A. Meyer, in Treg cell differentiation were examined. The results demonstrated that ginsenoside Rd induced Treg differentiation by upregulating Foxp3 expression and increased the generation of TGF-β1, IL-10 and IL-35. The data suggest that ginsenoside Rd may be a potential immunomodulating agent or supplement that can be applied for transplantation and autoimmune disorders.
Korean red ginseng, Ginsenoside, Regulatory T cell, Foxp3
Food Science and Biotechnology 2018 ; 27(1): 227-232