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¡æ Çѱ¹½Äǰ°úÇÐȸÁö2017 ; 49(06): 676-684
Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice
D-galactosamine/lipopolysaccharide·Î °¨ÀÛµÈ ±Þ¼º°£µ¶¼º ¸¶¿ì½º ¸ðµ¨¿¡¼­ Àλ■¸ÅÃßÃâ¹°ÀÇ °£µ¶¼º °³¼± È¿°ú
Su Kil Jang¢Ó, Jun Sub Park¢Ó, Jeong Won Ahn, Boram Jo, Hyun Soo Kim, JeongHoon Kim, Sang Yun Kim, Jung Youl Park1, Do Ik Lee2, Hee Yong Park2, and Seong Soo Joo*
College of Life Science, Gangneung-Wonju National University 1Department of Applied Chemistry, Daejeon University 2College of Pharmacy, Chung-Ang University
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ABSTRACT
The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNF¥á was normalized in 8 h after the treatment with D-GalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver.
KEYWORD
ginseng berry, D-galactosamine/lipopolysaccharide, non-alcoholic fatty liver disease, ginsenoside, linoleic acid
Çѱ¹½Äǰ°úÇÐȸÁö 2017 Dec; 49(06): 676 - 684
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