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한국식품과학회지
→ 한국식품과학회지2017 ; 49(06): 676-684
Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice
D-galactosamine/lipopolysaccharide로 감작된 급성간독성 마우스 모델에서 인삼열매추출물의 간독성 개선 효과
Su Kil Jang, Jun Sub Park, Jeong Won Ahn, Boram Jo, Hyun Soo Kim, JeongHoon Kim, Sang Yun Kim, Jung Youl Park1, Do Ik Lee2, Hee Yong Park2, and Seong Soo Joo*
College of Life Science, Gangneung-Wonju National University 1Department of Applied Chemistry, Daejeon University 2College of Pharmacy, Chung-Ang University
장수길·박준섭·안정원·조보람·김현수·김정훈·김상윤·박정열1·이도익2·박희용2·주성수*
강릉원주대학교 생명과학대학 생물의약신소재연구실, 1대전대학교 응용화학과, 2중앙대학교 약학대학 면역질환연구실
ABSTRACT
The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNFα was normalized in 8 h after the treatment with D-GalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver.
KEYWORD
ginseng berry, D-galactosamine/lipopolysaccharide, non-alcoholic fatty liver disease, ginsenoside, linoleic acid
한국식품과학회지 2017 Dec; 49(06): 676 - 684
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