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¡æ Çѱ¹½Äǰ°úÇÐȸÁö2017 ; 49(06): 649-658
Ethyl acetate fraction from Pteridium aquilinum ameliorates cognitive impairment in high-fat diet-induced diabetic mice
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Bong Seok Kwon¢Ó, Tian Jiao Guo¢Ó, Seon Kyeong Park, Jong Min Kim, Jin Yong Kang, Sang Hyun Park, Jeong Eun Kang, Chang Jun Lee, Uk Lee1, and Ho Jin Heo*
Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University 1Division of Special Purpose Tree, National Institute of Forest Science
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ABSTRACT
The potential of the ethyl acetate fraction from Pteridium aquilinum (EFPA) to improve the cognitive function in high-fat diet (HFD)-induced diabetic mice was investigated. EFPA-treatment resulted in a significant improvement in the spatial, learning, and memory abilities compared to the HFD group in behavioral tests, including the Y-maze, passive avoidance, and Morris water maze. The diabetic symptoms of the EFPA-treated groups, such as fasting glucose and glucose tolerance, were alleviated. The administration of EFPA reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) content in mice brains, but increased the acetylcholine (ACh) and superoxide dismutase (SOD) levels. Finally, kaempferol-3-o-glucoside, a major physiological component of EFPA, was identified by using high-performance liquid chromatography coupled with a hybrid triple quadrupole-linear ion trap mass spectrometer (QTRAP LC-MS/MS).
KEYWORD
cognitive function, diabetes, high-fat diet, Pteridium aquilinum
Çѱ¹½Äǰ°úÇÐȸÁö 2017 Dec; 49(06): 649 - 658
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