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한국식품과학회지
→ 한국식품과학회지2017 ; 49(06): 649-658
Ethyl acetate fraction from Pteridium aquilinum ameliorates cognitive impairment in high-fat diet-induced diabetic mice
고지방 식이로 유도된 실험동물의 당뇨성 인지기능 장애에 대한 고사리 아세트산에틸 분획물의 개선효과
Bong Seok Kwon, Tian Jiao Guo, Seon Kyeong Park, Jong Min Kim, Jin Yong Kang, Sang Hyun Park, Jeong Eun Kang, Chang Jun Lee, Uk Lee1, and Ho Jin Heo*
Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University 1Division of Special Purpose Tree, National Institute of Forest Science
권봉석·궈텐쟈오·박선경·김종민·강진용·박상현·강정은·이창준·이 욱1·허호진*
경상대학교 응용생명과학부(BK21 plus)·농업생명과학연구원, 1국립산림과학원 특용자원연구과
ABSTRACT
The potential of the ethyl acetate fraction from Pteridium aquilinum (EFPA) to improve the cognitive function in high-fat diet (HFD)-induced diabetic mice was investigated. EFPA-treatment resulted in a significant improvement in the spatial, learning, and memory abilities compared to the HFD group in behavioral tests, including the Y-maze, passive avoidance, and Morris water maze. The diabetic symptoms of the EFPA-treated groups, such as fasting glucose and glucose tolerance, were alleviated. The administration of EFPA reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) content in mice brains, but increased the acetylcholine (ACh) and superoxide dismutase (SOD) levels. Finally, kaempferol-3-o-glucoside, a major physiological component of EFPA, was identified by using high-performance liquid chromatography coupled with a hybrid triple quadrupole-linear ion trap mass spectrometer (QTRAP LC-MS/MS).
KEYWORD
cognitive function, diabetes, high-fat diet, Pteridium aquilinum
한국식품과학회지 2017 Dec; 49(06): 649 - 658
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