Food Science and Biotechnology
→ Food Science and Biotechnology 2016 ; 25(S): 133-141
Beneficial Role and Function of Fisetin in Skin Health via Regulation of the CCN2/TGF-β Signaling Pathway
Myung-Soo Shon, Ryeong-Hyeon Kim, O Jun Kwon1, Seong-Soo Roh2, and Gyo-Nam Kim*
Department of Food, Nutrition and Biotechnology, Kyungnam University, Changwon 51767, Korea 1Daegyeong Institute for Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation, Daegu 38542, Korea 2Department of Herbology, Daegu Haany University, Daegu 42158, Korea
Skin is composed of multiple layers, including the epidermis, dermis, and hypodermis. Although several biological activities of fisetin have been reported, beneficial effects and the functions of fisetin in skin remain unclear. B16F10 melanoma cells, human skin fibroblasts, and 3T3-L1 cells were used to examine the beneficial effects of fisetin in skin health. α-MSH- and IBMX-induced melanosis in B16F10 melanoma cells was inhibited by fisetin treatment, which also enhanced mRNA expression levels of skin fibril-related genes via the CCN2/TGF-β signaling pathway. Decreased intracellular lipid accumulation via down-regulation of transcriptional factors through activation of the CCN2/TGF-β signaling pathway was observed. A novel function of fisetin in skin health via down-regulation of melanosis and adipogenesis, and up-regulation of skin fibril-related genes was observed. Evidence for development of nutri-cosmetics for skin health is presented.
CCN2, TGF-β, fisetin, skin, melanoma
Food Science and Biotechnology 2016 ; 25(S): 133-141