→ 한국식품과학회지2021 ; 53(5): 561-569
Preventive effects of blackcurrant on glomerular fibrosis and renal dysfunction in a diabetic nephropathy model
당뇨병성 신병증 모델에서 블랙커런트의 사구체 섬유증 및 신장 기능장애 개선 효과
Hye Yoom Kim1,2,*
1Department of Physiology, College of Oriental Medicine, Wonkwang University 2Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University
김 혜 윰1,2,*
1원광대학교 한의과대학 생리학교실, 2한방심신증후군연구센터
Diabetic nephropathy is a major and representative complication of type 2 diabetes. Hyperglycemia increases the incidence of diabetic nephropathy, and induces kidney inflammation, thereby causing renal fibrosis, which is an important factor in the pathogenesis of diabetic nephropathy. This study investigated the effects of blackcurrant extract (BLC), which has been implicated in diabetic nephropathy in db/db mice, on glomerular fibrosis and renal dysfunction. The results showed that BLC consumption in type 2 diabetic db/db mice ameliorated diabetes-related metabolic disorders, such as insulin resistance and renal dysfunction, and significantly attenuated renal inflammation and renal fibrosis in diabetic nephropathy. In conclusion, these findings suggest that BLC consumption may help prevent renal fibrosis, inflammation, and consequent diabetic nephropathy.
Blackcurrant, diabetes mellitus, diabetic nephropathy, renal dysfunction, renal inflammation
한국식품과학회지 2021 Oct; 53(5): 561 - 569