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한국식품과학회지
→ 한국식품과학회지2021 ; 53(5): 544-552
Effect of Paeoniae Radix Alba on a thioacetamide induced liver fibrosis mice model
Thioacetamide로 유발된 간섬유증 동물 모델에서 백작약이 미치는 효능
Se Hui Lee1, Jin A Lee1, Mi-Rae Shin1, Bu-Il Seo1, and Seong-Soo Roh1,*
1Department of Herbology, College of Korean Medicine, Daegu Haany University
이세희1 · 이진아1 · 신미래1 · 서부일1 · 노성수1,*
1대구한의대학교 한의과대학 본초약리학교실
ABSTRACT
This study investigated the anti-fibrotic and antioxidant effects of Paeonia Radix Alba water extract (PR) on thioacetamide (TAA)-induced liver fibrosis in a mouse model and its underlying mechanisms. Liver fibrosis was induced by intraperitoneal injection of TAA (three times a week) for 8 weeks. Furthermore, silymarin (50 mg/kg body weight) and PR (200 mg/kg body weight) were administered for 8 weeks. PR treatment downregulated aspartate aminotransferase (AST), alanine aminotransferase (ALT), ammonia, and myeloperoxidase levels. Moreover, PR treatment downregulated NOX2 and p47phox and upregulated antioxidant enzymes by activating the Nrf2/Keap1 signaling pathway. Furthermore, PR inhibited the factors associated with fibrosis, such as α-SMA and collagen I. AMPK/SIRT1 was upregulated by PR treatment. Overall, these results suggest that PR attenuates liver fibrosis by regulating the Nrf2/Keap1 and AMPK/SIRT1/ NF-κB signaling pathways through the inhibition of oxidative stress. Hence, PR has potential as a remedy for preventing and treating liver fibrosis.
KEYWORD
liver fibrosis, Paeoniae Radix Alba, oxidative stress, antioxidant, thioacetamide
한국식품과학회지 2021 Oct; 53(5): 544 - 552
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