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Food Science and Biotechnology
→ Food Science and Biotechnology 2021 ; 30(9): 1257-1268
Anti-asthma and antitussive effects of a fermented extract of a mixture of Ramulus mori, Anthriscus sylvestris, and Salvia plebeian
Mirae An1 • Miae Oh2 • Keun-Tae Park2 • Ki Hwan Seon3 • Jeong Eun Jo3 • Seong Kweon Lee3 • Jeong-Keun Kim4 • Kwang Soon Shin5 • Jong-Ho Koh6 • Young-Hee Lim2,7,8
1 Department ofPublic Health Science, Graduate School, Korea University, Seoul 02841, Republic of Korea 2 Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea 3 R & D Center, Biocean CO. LTD, Seoul 08591, Republic of Korea 4 Department of Chemical Engineering and Biotechnology, Korea Polytechnic University, Shihung-si, Gyeonggi-do 15073, Republic of Korea 5 Department of Food Science and Biotechnology, Kyonggi University, Suwon 16227, Republic of Korea 6 Department of Bio-Food Analysis and Processing, Bio-Campus Korea Polytechnic College, Nonsan 32943, Republic of Korea 7 School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul 02841, Republic of Korea 8 Department of Laboratory Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
ABSTRACT
Respiratory immunity is getting more important recently due to outbreak of respiratory diseases and increasing the concentration of fine dust. The aim of this study was to investigate respiratory protection effect of a fermented extract of medicinal plants (FEMP) containing Ramulus mori, Salvia plebeia, and Anthriscus sylvestris. The expression levels of IL-8 and IL-17 in LPS/poly-Larginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells. The levels of IgE, IL-17, and IL-4 in the bronchoalveolar lavage fluid (BALF) and serum of FEMP-treated mice with ovalbumin/LPS-induced asthma were lower than the control levels. The lung inflammation score and the number of inflammatory cells in the BALF decreased by FEMP treatment. In the citric acid-induced coughing guinea pig, the FEMP treatment decreased the number of coughs. Therefore, FEMP shows anti-asthmatic and antitussive activities without hepatotoxicity and can be used as a compound aiming to improve respiratory health.
KEYWORD
Anti-asthma · Antitussive · Anti-inflammation · Fermented extract of medicinal plant
Food Science and Biotechnology 2021 ; 30(9): 1257-1268
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