→ 한국식품과학회지2021 ; 53(1): 72-77
Evaluation of the effects of Hangover-releasing agent containing freeze-dried mature silkworm larval powder (SMSP) on alcohol metabolism and hangover improvement
숙잠 함유 복합물의 알코올 대사 및 숙취개선 효능평가
Miseon Woo1†, Ji Hyeon Cha2†, Yonghwan Kim3†, Hee-Taik Kang3,4, Hyeondok Kim1, Kyong Won Cho1, Sung Sun Park1,*, and Jong Hun Lee2
1Chong Kun Dang Healthcare Corporation 2Department of Food Science and Bioechnology, Gachon University 3Department of Family Medicine, Chungbuk National University Hospital 4Department of Family Medicine, Chungbuk National University College of Medicine
우미선1† ·차지현2† ·김용환3† ·강희택3,4 ·김현덕1 ·조경원1 ·박성선1,* ·이종훈2
1종근당건강(주) R&D본부, 2가천대학교 식품생물공학과, 3충북대학교 의과대학 가정의학교실, 4충북대학교 의과대학
Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.
hangover improvement, silkworm (Bombyx mori) powder, alcohol metabolism, clinical trail research, cross-over model
한국식품과학회지 2021 Feb; 53(1): 72 - 77