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Food Science and Biotechnology
→ Food Science and Biotechnology 2020 ; 29(8): 1101-1112
Anti-hyperglycemic and hypolipidemic effects of black ginseng extract containing increased Rh4, Rg5, and Rk1 content in muscle and liver of type 2 diabetic db/db mice
Yu-Jin Jeong1 • Moon-Jung Hwang1 • Chung-Oui Hong2 • Dae-Seok Yoo3 • Jin Seong Kim3 • Do-Yeon Kim3 • Kwang-Won Lee1
1 Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Anam-Dong, Sungbuk-Gu, Seoul 02841, Korea 2 Herbal Crop Research Division, RDA, Bisanro 92, Eumseong, Chungbuk 27709, Republic of Korea 3 International Ginseng & Herb Research Institute, 25 Insamgwangjang-ro, Geumsan-eup, Geumsan-gun, Chungnam 32724, Republic of Korea
ABSTRACT
Black ginseng (BG), which is produced by repeated steaming and drying of fresh ginseng, has various pharmacological and therapeutic properties. This study investigated the anti-hyperglycemic and hypolipidemic effects of BG ethanolic extract in type 2 diabetic db/db mice. The levels of fasting blood glucose, HbA1c, insulin levels and thiobarbituric acid reactive substances values were decreased in the groups fed BG extract (BG) (100 and 900 mg/kg BW/day), compared to the control group (CON). In the BG compared with the CON, hepatic steatosis in the liver and the size of adipocytes in muscle tissue were improved. The administration of BG regulated the glucose transporter type (GLUT) 4 and 2, and peroxisome proliferator-activated receptor (PPAR) α and γ in muscle and liver. Moreover, ginsenosides (Rh4, Rg5, and Rk1), which profiled by HPLC, regulated the markers for lipid metabolism and glucose metabolism; PPARs and GLUTs in muscle and C2C12 rather than liver cells and tissue. These findings suggested that ginsenosides (Rh4, Rg5, and Rk1) from BG extract can ameliorate type 2 diabetes through their anti-hyperglycemic and hypolipidemic effects.
KEYWORD
Black ginseng ∙ Anti-hyperglycemic ∙ Hypolipidemic ∙ Type 2 diabetic db/db mice
Food Science and Biotechnology 2020 ; 29(8): 1101-1112
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