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한국식품과학회지
→ 한국식품과학회지2020 ; 52(3): 263-273
Ameliorative effect of onion (Allium Cepa L.) flesh and peel on amyloid-β-induced cognitive dysfunction via mitochondrial activation
미토콘드리아 활성화를 통한 양파(Allium Cepa L.) 과육 및 과피의 Amyloid-β 유도성 인지손상에 대한 개선효과
Seon Kyeong Park1, Uk Lee2, Jin Yong Kang1, Jong Min Kim1, Eun Jin Shin1, and Ho Jin Heo1,*
1Division of Applied Life Science (BK21 Plus), Institute of Agriculture and Life Science, Gyeongsang National University 2Division of Special Forest Products, National Institute of Forest Science
박선경1·이 욱2·강진용1·김종민1·신은진1·허호진1,*
1경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원, 2국립산림과학원, 산림소득자원연구과
ABSTRACT
In this study, in order to confirm the ameliorative effects of onion (Allium cepa L.) flesh and peel on amyloidbeta (Aβ)-induced cognitive dysfunction, we evaluated their in vitro neuroprotection and in vivo cognitive functions. As the result of in vitroneuroprotection, the protective effect of the ethyl acetate fraction of onion flesh (EOF) on Aβ-induced cytotoxicity was similar to that of the ethyl acetate fraction of onion peel (EOP). In the behavioral tests, the EOF and EOP effectively improved the Aβ-induced learning and memory impairments. For this reason, it could be concluded that the EOF and EOP improved the antioxidant activities (superoxide dismutase, oxidized glutathione/total glutathione, and malondialdehyde) in brain tissue. In addition, the EOF and EOP effectively activated mitochondrial functions by protecting the mitochondrial membrane potential, ATP, mitochondria-mediated protein (BAX and cytochrome c), and caspase 3/7 activities. The EOF and EOP also improved the cholinergic system (acetylcholinesterase and acetylcholine). Therefore, we suggest that onion could be used for management of Aβ-induced cognitive dysfunction.
KEYWORD
Allium cepa L., amyloid-β, cognition, cholinergic system, mitochondrial function
한국식품과학회지 2020 Jun; 52(3): 263 - 273
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