→ 한국식품과학회지2020 ; 52(3): 255-262
Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice
Hyun Kyung Kim1, Jiyeon Jung1, Eun Young Kang1, Gyoungok Gang2, Wooki Kim3, and Gwang-woong Go1,*
1Department of Food and Nutrition, Hanyang University 2Department of Animal Science, Texas A&M University 3Department of Food Science and Biotechnology, Kyung Hee University
Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD +A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.
anti-obesity therapeutic, Aronia melanocarpa, hormone-sensitive lipase, lipolysis, respiratory quotient
한국식품과학회지 2020 Jun; 52(3): 255 - 262