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한국식품과학회지
→ 한국식품과학회지2020 ; 52(3): 249-254
Evaluation of anti-inflammatory effect by regulating NF-κB pathway of Argyreia capitata (Vahl) Choisy extract in LPS-induced RAW 264.7 macrophages
LPS로 유도된 RAW 264.7 대식세포에서 Argyreia capitata (Vahl) Choisy 추출물의 NF-κB pathway 조절을 통한 항염증 효능 평가
Ga Hee Yeum1, Bo Ram So1, Tran The Bach2, Sang Mi Eum3, and Sung Keun Jung1,*
1School of Food Science and Biotechnology, Kyungpook National University 2Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology (VAST) 3International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology
염가희1·소보람1·Tran The Bach2·엄상미3·정성근1,*
1경북대학교 식품공학부 식품응용공학전공, 2베트남 과학기술원, 생태생물자원 연구소, 3한국생명공학연구원, 해외생물소재센터
ABSTRACT
Argyreia capitata (Vahl) Choisy is a species of the genus Argyreia. Although many studies have analyzed the biological activity of A. nervosa, A. speciasa, and A. acuta, the anti-inflammatory effect of A. capitata extract (ACE) remains unclear. In this study, we evaluated the anti-inflammatory effect of ACE using lipopolysaccharide (LPS)-induced inflammatory markers in RAW 264.7 cells. We confirmed that the ACE inhibited the LPS-induced NO (nitric oxide) and iNOS (inducible nitric oxide synthase) expression in RAW 264.7 cells. ACE suppressed not only the LPS-induced phosphorylation of IKK, IκB, and p65 but also IL-1β expression. Collectively, these results suggest that ACE is a novel anti-inflammatory agent that suppresses iNOS expression, NO production, and the NF-κB signaling pathways.
KEYWORD
Argyreia capitata (Vahl) Choisy extract (ACE), nitric oxide (NO), NF-κB (nuclear factor kappa-B), inflammatory cytokines, anti-inflammatory effect
한국식품과학회지 2020 Jun; 52(3): 249 - 254
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