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Food Science and Biotechnology
→ Food Science and Biotechnology 2020 ; 29(6): 739-749
Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials
Humna Liaqat1 Eunseon Jeong1 Kyeong Jin Kim2 Ji Yeon Kim1,2
1Department of Food Science and Technology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea 2Department of Nano Bio Engineering, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea
ABSTRACT
This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of - 0.01 (95% confidence interval; - 0.17, 0.16). The SMD was - 0.06 (95% CI - 0.41, 0.29, n = 4) for triglycerides and - 0.09 (95% CI - 0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying.
KEYWORD
Wheat germㆍMetabolic markersㆍCholesterolㆍTriglyceridesㆍGlucose
Food Science and Biotechnology 2020 ; 29(6): 739-749
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