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Food Science and Biotechnology
→ Food Science and Biotechnology 2020 ; 29(2): 251-263
Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis
Hyun-Ji Park1 • Chul-Kyu Lee1 • Si-Hwan Song1 • Jee-Hye Yun2 • Ahsa Lee2 • Hee-Jung Park3
1 Gyeonggi Bio Research Center, Chemon Inc., Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi-do 16229, Korea 2 Handok Inc., 132 Teheran Street, Gangnam-gu, Seoul 06235, Korea 3 Department of Food and Nutrition, Yuhan University, 590 Gyeongin-ro, Bucheon-si, Gyeonggi-do 14780, Korea
ABSTRACT
This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin® (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weightbearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-a, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.
KEYWORD
Highly bioavailable curcumin · Monosodium iodoacetate · Osteoarthritis · Joint · Anti-arthritic effect
Food Science and Biotechnology 2020 ; 29(2): 251-263
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