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Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(6): 1599-1606
Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia
Youngjoo Kwon1
1Department of Food Science and Engineering, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
ABSTRACT
Benign prostatic hyperplasia (BPH) is a noncancerous growth of the prostate. BPH commonly occurs in elderly men. Lower urinary tract symptoms (LUTS) secondary to BPH (LUTS/BPH) have significant impacts on their health. Saw palmetto (Serenoa repens) extract (SPE) has been evaluated for its effectiveness in improvement of LUTS/BPH at preclinical and clinical levels. Potential mechanisms of actions include anti-androgenic, pro-apoptotic, and anti-inflammatory effects. However, SPE efficacy was inconsistent, at least partly due to a lack of a standardized SPE formula. A hexane extract (free fatty acids,> 80%) provided more consistent results. Free fatty acids (lauric acid) were effective in inhibition of 5a-reductase, and phytosterol (b-sitosterol) reduced prostatic inflammation. Multiple actions derived from different constituents may contribute to SPE efficacy. Evaluation of the clinical relevance of these bioactive components is required for standardization of SPE, thereby enabling consistent efficacy and recommendations for the use in the prevention and treatment of BPH.
KEYWORD
Benign prostatic hyperplasia · Fatty acids · Phytosterol · Saw palmetto extract · Standardized formula
Food Science and Biotechnology 2019 ; 28(6): 1599-1606
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