→ 한국식품과학회지2019 ; 51(4): 398-403
Enhancement of immune activities of Dioscorea japonica Thunberg in in vivo and ex vivo models
Seokwon Lim1,†, Na-Hyung Kim2,†, Hi-Jae Cho3, and Hyun-Ja Jeong1,*
1Division of Food and Pharmaceutical Engineering, 2Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 3Dongsan Natural Products Co.
Dioscorea japonica Thunberg (DJ) has been widely used as a healthy food in Korea for the enhancement of physical stamina. Hence, the present study evaluated the immune-enhancing effect of DJ in forced swim test of mouse model. The immobility time of the group treated with DJ for 7 days was significantly reduced in comparison with that of the control group. After a forced swimming test, the changes in blood biochemical parameters and splenic T lymphocyte populations induced by the administration of DJ were assessed. Serum levels of lactic dehydrogenase, creatine phosphokinase, and aspartate aminotransferase were significantly decreased in DJ-administered group compared to the control group. However, administration of DJ did not affect the splenic T lymphocyte populations. Moreover, DJ significantly increased the production of interferon-g and interleukin-2 compared to the media control in splenocytes. Collectively, it may be concluded that DJ is useful for enhancement of physical and immune function.
Dioscorea japonica Thunberg, forced swimming test, interferon-g, interleukin-2, immune-enhancement
한국식품과학회지 2019 Aug; 51(4): 398 - 403