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한국식품과학회지
→ 한국식품과학회지2019 ; 51(4): 398-403
Enhancement of immune activities of Dioscorea japonica Thunberg in in vivo and ex vivo models
Seokwon Lim1,†, Na-Hyung Kim2,†, Hi-Jae Cho3, and Hyun-Ja Jeong1,*
1Division of Food and Pharmaceutical Engineering, 2Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 3Dongsan Natural Products Co.
ABSTRACT
Dioscorea japonica Thunberg (DJ) has been widely used as a healthy food in Korea for the enhancement of physical stamina. Hence, the present study evaluated the immune-enhancing effect of DJ in forced swim test of mouse model. The immobility time of the group treated with DJ for 7 days was significantly reduced in comparison with that of the control group. After a forced swimming test, the changes in blood biochemical parameters and splenic T lymphocyte populations induced by the administration of DJ were assessed. Serum levels of lactic dehydrogenase, creatine phosphokinase, and aspartate aminotransferase were significantly decreased in DJ-administered group compared to the control group. However, administration of DJ did not affect the splenic T lymphocyte populations. Moreover, DJ significantly increased the production of interferon-g and interleukin-2 compared to the media control in splenocytes. Collectively, it may be concluded that DJ is useful for enhancement of physical and immune function.
KEYWORD
Dioscorea japonica Thunberg, forced swimming test, interferon-g, interleukin-2, immune-enhancement
한국식품과학회지 2019 Aug; 51(4): 398 - 403
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