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한국식품과학회지
→ 한국식품과학회지2019 ; 51(4): 393-397
Effects of persimmon leaf extracts on proteasome activity in HepG2 human liver cancer cells
감잎 추출물이 HepG2 인간 간암 세포의 proteasome 활성에 미치는 영향
Soyoung Kim1 and Hyungeun Yoon2,*
1Department of Food and Nutrition, Sungshin Women’s University, 2Department of Food science and biotechnology, Sungshin Women’s University
김소영1·윤현근2,*
1성신여자대학교 식품영양학과, 2성신여자대학교 바이오식품공학과
ABSTRACT
Proteasome inhibitors can promote apoptosis and cell cycle arrest in cancer cells by inhibition of nuclear factorkappaB (NF-κB) activation. The purpose of this study was to investigate the effects of persimmon leaf extract (PSE) on proteasome activity in HepG2 human liver cancer cells. PSE treatment inhibited the proteasome activity and NF-κB activation in a dose-dependent manner in HepG2 human liver cancer cells (p<0.05). PSE treatment increased the population of cells in G2/M and sub-G1 phases. The results suggested that PSE is one of the candidate substances that may be developed into a proteasome inhibitor.
KEYWORD
proteasome inhibitor, NF-κB, persimmon leaf extracts, HepG2 cells
한국식품과학회지 2019 Aug; 51(4): 393 - 397
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