→ 한국식품과학회지2019 ; 51(4): 361-368
Effects of Dendropanax morbifera extracts on postmenopausal syndrome in ovariectomized rats
황칠추출분말이 난소적출 흰쥐의 여성 갱년기 증상에 미치는 영향
Ga-hui Oh1,*, Sung-moon Oh1, Seung-sik Lee1, Ji-hyeon Kim2, Jueon Oh2, Young-joon Park3, and Joo-eun Kim4
1RIHU Healthcare Co., 2CI Bio convergence institute, CROEN, Co., 3Ajou University, 4Catholic University of Daegu
1리후헬스케어(주), 2크로엔, 3아주대학교, 4대구가톨릭대학교
The present study aimed to evaluate the effect of Dendropanax morbifera (DM) extract on postmenopausal syndrome and to develop DM extract as an alternative for hormonal therapy. The following seven groups of rats; normal control (sham), ovariectomized (OVX) control, Punica granatum (PG)-treated group (770 mg/kg), estradiol treated group (0.5 mg/kg), and three DM-treated groups (200, 500, 1000 mg/kg) were compared. Indicated compounds were administrated once a day for eight weeks. To evaluate the estrogenic effect of DM extract, western blot analysis was performed on the liver tissue to confirm the expression of estrogen receptor (ER-α, ER-β). Our analysis showed that after DM administration, collagen cross-linked C-telopeptide (CTX) value decreased while ER-α protein expression increased in a dose-dependent manner through the MAPK/ERK pathway in OVX rats. These results suggest that Dendropanax morbifera exerts estrogenic effect by inducing estrogen receptor expression and activating MAPK/ERK pathway.
Dendropanax morbifera, phytoestrogen, rutin, ovariectomized rats, menopausal syndrome
한국식품과학회지 2019 Aug; 51(4): 361 - 368