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Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(3): 907-911
Postprandial anti-hyperglycemic effect of vitamin B6 (pyridoxine) administration in healthy individuals
Hyuk Hwa Kim1, Yu-Ri Kang2, Hwang-Yong Choi2, Jung-Yun Lee2, Jung-Bae Oh3, Justin S. Kim4, Young-Cheul Kim4, Ki Won Lee1, Young-In Kwon2
1Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea 2Department of Food and Nutrition, Hannam University, Daejeon, Korea 3Institute of KPB, Kunpoong Bio Co., Ltd, Seoul, Jeju Special Self Governing Province, Korea 4Department of Nutrition, University of Massachusetts, Amherst, MA 01003, USA
ABSTRACT
Postprandial blood glucose lowering effect of vitamin B6 (pyridoxine) was evaluated in healthy individuals with normal blood glucose levels. Blood glucose levels were measured every 30 min for 2 h after oral sugar administration with or without 50 mg of pyridoxine. Pyridoxine significantly lowered the postprandial blood glucose levels at 30 min (from 165.95 ± 17.19 to 138.36 ± 20.43, p<0.01) and 60 min (from 131.40 ± 17.20 to 118.50 ± 15.95) after administration. In addition, the area under the concentration–time curve (AUCt) was reduced by about 8.3% (from 257.08 ± 22.38 to 235.71 ± 12.33, p<0.05) and the maximum concentration of blood glucose (Cmax) was reduced by about 13.8% (from 165.95 ± 17.19 to 143.07 ± 11.34, p<0.01) when compared with those of the control group. Our findings suggest that pyridoxine supplementation may be beneficial for controlling postprandial hyperglycemia.
KEYWORD
Pyridoxine, Pyridoxine hydrochloride, Vitamin B6, Anti-hyperglycemic effects, Healthy individuals, Postprandial hyperglycemia
Food Science and Biotechnology 2019 ; 28(3): 907-911
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