Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(3): 873-879
Green satsuma mandarin orange (Citrus unshiu) extract reduces adiposity and induces uncoupling protein expression in skeletal muscle of obese mice
Jeong Kee Kim1, Hyun Woo Jeong2, A Young Kim2, Yong Deog Hong2, Ji Hae Lee2, Jin Kyu Choi3, Jae Sung Hwang1
1Department of Genetic Engineering and Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea 2Vital Beautie Research Division, Amorepacific R&D Center, 1920 Yonggu-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17074, Republic of Korea 3QA Team, Aestura Corporation, Gongdan1-ro 36, Ansung-si, Gyeonggi-do 17575, Republic of Korea
Increased fat mass, which is induced by the storage of excess nutrients, is considered a causal factor for various metabolic disorders, including insulin resistance, type 2 diabetes, hyperlipidemia, hyperglycemia, hypertension, atherosclerosis, and non-alcoholic fatty liver disease. Therefore, it is necessary to prevent hyperadiposity to sustain a healthy life. Recently, uncoupling proteins (UCPs) were suggested to be molecular targets for curing obesity and its complications. In this study, green satsuma mandarin orange (Citrus unshiu) extract (GME) increased UCP3 expression in cultured myocytes. In a diet-induced obese animal model, administration of GME reduced fat mass and average fat cell size. Similar to in vitro experiments, GME restored expression of UCP3 in skeletal muscle. Moreover, GME also induced UCP2 expression in skeletal muscle. In conclusion, GME is suggested to be a novel functional dietary supplement for adiposity control through induction of UCPs.
Green mandarin orange, Hesperidin, UCP3, Adiposity, Muscle
Food Science and Biotechnology 2019 ; 28(3): 873-879