HOME | LOGIN | MEMBER JOIN | CONTACT US | ENGLISH

Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(3): 857-864
The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats
Pu Reum Seok1, Su Jin Oh1, Jin Woo Choi1, Cho Rong Lim1, Jong Ryeol Choi2, Jung Hoan Kim3, Jae-Ho Shin1
1Department of Senior Healthcare, BK21 Plus Program, Graduate School, Eulji University, Seongnam-si, Gyunggi-do 13135, Republic of Korea 2Muju Wellness Food Project Team, Jeonju University, Jeonju-si, Jeonrabuk-do 55069, Republic of Korea 3Department of Food Technology and Service, Eulji University, Seongnam-si, Gyunggi-do 13135, Republic of Korea
ABSTRACT
To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
KEYWORD
Middle cerebral artery occlusion, Brain ischemia, Gastrodia elata Blume, 4-Hydroxybenzyl alcohol, Rat
Food Science and Biotechnology 2019 ; 28(3): 857-864
List