→ 한국식품과학회지2019 ; 51(2): 160-168
Double-processed ginseng berry extracts enhance learning and memory in an Aβ42-induced Alzheimer’s mouse model
Aβ42로 유도된 알츠하이머 마우스 모델에서 이중 가공 인삼열매 추출물의 학습 및 기억 손실 개선 효과
Kil Jang1,#, Jeong Won Ahn1,#, Boram Jo1, Hyun Soo Kim1, Seo Jin Kim1, Eun Ah Sung1, Do Ik Lee2, Hee Yong Park2, Duk Hee Jin1, and Seong Soo Joo1,*
1College of Life Science, Gangneung-Wonju National University, 2College of Pharmacy, Chung-Ang University
1강릉원주대학교 생명과학대학 생물의약신소재연구실, 2중앙대학교 약학대학 면역질환연구실
This study aimed to determine whether double-processed ginseng berry extract (PGBC) could improve learning and memory in an Aâ42-induced Alzheimer’s mouse model. Passive avoidance test (PAT) and Morris water-maze test (MWMT) were performed after mice were treated with PGBC, followed by acetylcholine (ACh) measurement and glial fibrillary acidic protein (GFAP) detection for brain damage. Furthermore, acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression were analyzed using Ellman’s and qPCR assays, respectively. Results demonstrated that PGBC contained a high amount of ginsenosides (Re, Rd, and Rg3), which are responsible for the clearance of Aâ42. They also helped to significantly improve PAT and MWMT performance in the Aâ42-induced Alzheimer’s mouse model when compared to the normal group. Interestingly, ACh and ChAT were remarkably upregulated and AChE activities were significantly inhibited, suggesting PGBC to be a palliative adjuvant for treating Alzheimer’s disease. Altogether, PGBC was found to play a positive role in improving cognitive abilities. Thus, it could be a new alternative solution for alleviating Alzheimer’s disease symptoms.
processed ginseng berry extract, passive avoidance test, Morris water-maze test, acetylcholine, choline, acetyltransferase
한국식품과학회지 2019 Apr; 51(2): 160 - 168