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Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(2): 563-568
Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice
Junghyun Kim1,2, Soo-Wang Hyun1, Ik Soo Lee1, Kyuhyung Jo1, Young Sook Kim1, Jin Sook Kim1, Chan-Sik Kim1,3
1Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yusengdae-ro, Daejeon 34054, Republic of Korea, 2Department of Oral Pathology, School of Dentistry, Chonbuk National University, Jeonju 54896, Republic of Korea, 3Korean Medicine Life Science, University of Science Technology (UST), Daejeon 34113, Republic of Korea
ABSTRACT
The <i>Aster koraiensis</i> extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose tolerance tests (OGTTs). In a long-term efficacy study, 4 weeks of oral ASKO treatment significantly attenuated blood glucose levels during OGTTs in diet-induced obese (DIO) mice. ASKO also enhanced plasma insulin levels after glucose loading, leading to a reduction in blood glucose levels. In addition, ASKO normalized glucose transporter-4 mRNA expression in the muscles of DIO mice. These results indicate that ASKO has postprandial glucose-lowering effects and could be beneficial in the management of prediabetes or type 2 diabetes mellitus.
KEYWORD
Aster koraiensis, Glucose transporter, Postprandial glucose, Type 2 diabetes mellitus
Food Science and Biotechnology 2019 ; 28(2): 563-568
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