HOME | LOGIN | MEMBER JOIN | CONTACT US | ENGLISH

Food Science and Biotechnology
→ Food Science and Biotechnology 2019 ; 28(2): 519-528
Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats
Zhaojun Chen1, Yongxiang Liu1, Hui Wang1, Zhongai Chen1, Jia Liu1, Hui Liu1
1The Potato Institute of Guizhou Province, Guizhou Academy of Agricultural Sciences, Guiyang 550000, Guizhou, People’s Republic of China
ABSTRACT
The objective of this study was to determine the effects of sanshoamides and capsaiciniods on plasma and liver lipid levels and the mRNA expression levels of key receptors involved in cholesterol metabolism in hyperlipidemic rats. A total of 56 three-week-old female Sprague–Dawley rats were assigned to 7 treatment groups based on initial body weight (n = 8 rats per group). With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats. These results indicated that dietary supplementation with sanshoamides and capsaicinoids reduced blood lipid levels and improved cholesterol metabolism in hyperlipidemic rats.
KEYWORD
Capsaicinoid, Cholesterol metabolism, Hyperlipidemic rat, Sanshoamide
Food Science and Biotechnology 2019 ; 28(2): 519-528
List