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한국식품과학회지
→ 한국식품과학회지2019 ; 51(1): 81-89
Anti-obesity effect of 3,5-dicaffeoylquinic acid on high-fat diet mouse
고지방식이 마우스에서 3,5-dicaffeoylquinic acid의 항비만 효과
Jin Yong Kang1, Seon Kyeong Park1, Jong Min Kim1, Su Bin Park1, Seul Ki Yoo1, Hye Ju Han1, Dae Ok Kim2, and Ho Jin Heo1,*
1Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University, 2Department of Food Science and Biotechnology, Kyung Hee University
강진용1·박선경1·김종민1·박수빈1·유슬기1·한혜주1·김대옥2·허호진1,*
1경상대학교 응용생명과학부(BK12 plus), 농업생명과학연구원, 2경희대학교 식품생명공학과
ABSTRACT
This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.
KEYWORD
3,5-dicaffeoylquinic acid, chlorogenic acid, obesity, p-AMPK, p-Akt
한국식품과학회지 2019 Feb; 51(1): 81 - 89
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