→ 한국식품과학회지2019 ; 51(1): 81-89
Anti-obesity effect of 3,5-dicaffeoylquinic acid on high-fat diet mouse
고지방식이 마우스에서 3,5-dicaffeoylquinic acid의 항비만 효과
Jin Yong Kang1, Seon Kyeong Park1, Jong Min Kim1, Su Bin Park1, Seul Ki Yoo1, Hye Ju Han1, Dae Ok Kim2, and Ho Jin Heo1,*
1Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University, 2Department of Food Science and Biotechnology, Kyung Hee University
1경상대학교 응용생명과학부(BK12 plus), 농업생명과학연구원, 2경희대학교 식품생명공학과
This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.
3,5-dicaffeoylquinic acid, chlorogenic acid, obesity, p-AMPK, p-Akt
한국식품과학회지 2019 Feb; 51(1): 81 - 89