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한국식품과학회지
→ 한국식품과학회지2019 ; 51(1): 70-80
Non-saponin fraction of red ginseng inhibits monocyte-to-macrophage differentiation and inflammatory responses in vitro
홍삼 비사포닌 분획의 단핵세포 분화와 염증반응에 대한 억제효과
Bobin Kang1, Chae Young Kim1, Jisu Hwang1, and Hyeon-Son Choi2,*
Bobin Kang1, Chae Young Kim1, Jisu Hwang1, and Hyeon-Son Choi2,*
강보빈1·김채영1·황지수1·최현선2,*
1고려대학교 보건과학대 의생명융합과학과, 2서울여자대학교 식품공학과
ABSTRACT
The aim of this study was to investigate the effects of red ginseng-derived non-saponin fraction (NSF) on inflammatory responses and monocyte-to-macrophage differentiation in RAW264.7 and THP-1. NSF effectively inhibited inflammatory responses by downregulating nitric oxide (NO) production and protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). NSF (2000 μg/mL) decreased the levels of NO, iNOS, and COX-2 by 33, 83, and 64%, respectively. NSF inhibited the differentiation of monocyte-to-macrophage by decreasing cell adherence along with downregulation of the cluster of differentiation molecule 11β (CD11β) and CD36. In addition, pro-inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin 6, and monocyte chemoattractant protein 1 (MCP-1), were significantly reduced with NSF treatment. The NSF-mediated inhibition of inflammatory responses was due to the regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). NSF effectively suppressed the translocation of NF-κB into the nucleus, while nuclear Nrf2 and its target protein, heme oxygenase-1, levels were significantly increased.
KEYWORD
Non-saponin fraction of red ginseng, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), inflammatory responses, monocyte-to-macrophage differentiation.
한국식품과학회지 2019 Feb; 51(1): 70 - 80
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