→ 한국식품과학회지2019 ; 51(1): 58-63
Antimelanogenic effect and whitening of crude polysaccharide fraction extracted from Perilla frutescens Britton var. acuta Kudo
자소엽(Perilla frutescens Britton var. acuta Kudo) 조다당의 멜라닌 생성 저해 및 미백효과
Eun-Ji Cho1 and Eui-Hong Byun1,2,*
1Department of Food Science and Technology, Kongju National University, 2Food Science Research Institute, Kongju National University
1공주대학교 식품공학과, 2공주대학교 식품과학연구소
In this study, the inhibitory effects of crude polysaccharide fractions separated from Perilla frutescens Britton var. acuta Kudo (PCP) on melanin synthesis and tyrosinase activity were observed. B16F10 melanoma cells were treated with 125 and 250 μg/mL of PCP for 24 hours. Using these optimal concentrations, inhibition of melanin synthesis inhibition was measured, and PCP treatment significantly reduced melanin synthesis induced by 3-isobutyl-1-methylxanthine (IBMX). In addition, western blotting analysis on B16F10 melanoma cells showed that PCP inhibited tyrosinase, microphthalmia-associated transcriptipn factor, tyrosinase related protein-1, and tyrosinase related protein-2 expression. Therefore, these results indicate that PCP may have potential inhibitory activity against melanin synthesis and may be a natural ingredient useful for the development of whitening materials in cosmetics and functional foods.
Perilla frutescens Britton var. acuta Kudo, tyrosinase, tyrosinase related protein-1, tyrosinase related protein-2, microphthalmia-associated transcription factor
한국식품과학회지 2019 Feb; 51(1): 58 - 63