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한국식품과학회지
→ 한국식품과학회지2019 ; 51(1): 52-57
Inhibitory effects of crude polysaccharide fractions from Annona muricata L. on melanogenesis
그라비올라 잎(Annona muricata L.) 조다당 분획분의 멜라닌 생성 저해 효과
Yi-Eun Kim1 and Eui-Hong Byun1,2,*
1Department of Food Science and Technology, Kongju National University, 2Food Science Research Institute, Kongju National University
김이은1·변의홍1,2,*
1공주대학교 식품공학과, 2공주대학교 식품과학연구소
ABSTRACT
The objective of this study was to evaluate the anti-melanogenic effects of crude polysaccharide fractions from Annona muricata L. (ALP) in 3-isobutyl-1-methylxanthine (IBMX) stimulating hormone-induced mouse B16F10 melanoma cells. The inhibitory effect of ALP on tyrosinase activity was approximately 33.88±0.79% at 5 mg/mL. Additionally, the B16F10 cellular tyrosinase and melanin synthesis inhibition activities by ALP were 54.21±4.76 and 56.74±6.97% at 250 μg/mL, respectively. Similarly, whitening-related protein tyrosinase, tyrosinase-related protein 1 (TRP-1) and TRP-2, and microphthalmia-associated transcription factor (MITF) were reduced by ALP treatment. These results indicated that ALP could be used as a functional cosmetic ingredient after confirming its whitening activity related to melanin content.
KEYWORD
Annona muricata L., tyrosinase, melanin synthesis, whitening activity, microphthalmia-associated transcription factor (MITF)
한국식품과학회지 2019 Feb; 51(1): 52 - 57
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