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한국식품과학회지
→ 한국식품과학회지2018 ; 50(05): 511-516
Immunomodulatory activities of polysaccharides extracted Cudrania tricuspidata fruits in macrophage
꾸지뽕(Cudrania tricuspidata) 열매에서 분리된 조다당의 큰포식세포 면역 활성 조절
Eun-Ji Cho1, Yi-Eun Kim1, and Eui-Hong Byun1,2,*
1Department of Food Science and Technology, Kongju National University, 2Food Science Research Institute, Kongju National University
조은지1·김이은1·변의홍1,2,*
1공주대학교 식품공학과, 2공주대학교 식품과학연구소
ABSTRACT
Macrophages play a crucial role in the host immune defense system. The current study investigated immunomodulatory activities induced by polysaccharides extracted from Cudrania tricuspidata (CTPS) fruits in murine macrophages and their role in signaling pathways. In macrophages, CTPS predominantly induced nitric oxide (NO), tumor necrosis factor-a, and interleukin-6 production. In addition, CTPS significantly up-regulated expression of the macrophage surface marker (CD80/ 86 and MHC class I/II). These results indicate that polysaccharides extracted from CTPS may potentially play an immunomodulatory role in macrophages via mitogen-activated protein kinases and nuclear factor-B signaling. These findings may be useful in the development of immune enhancing adjuvant materials obtained from natural sources.
KEYWORD
Cudrania tricuspidata fruits polysaccharide, immunomodulatory activity, macrophage, nitric oxide, cytokine
한국식품과학회지 2018 Oct; 50(05): 511 - 516
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